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Ocular Toxicity Testing
Ocular Toxicity Testing
Ocular Toxicity Testing

The development of an ocular toxicity testing platform offering innovative companies with an in-house, high-throughput testing solution providing early indications of ocular toxicity profile with reference to UN GHS classifications and reducing the reliance on animal testing.

Kerato’s Ocular Toxicity testing platform will provide innovative companies with an in-house, high-throughput testing solution providing early indications of ocular toxicity profile of novel chemical formulations with reference to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals.

Our platform will reduce industry reliance on animal testing.


Man in lab using Keratox to evaluate ocular toxicity profile of chemical formulations.

Research Student Enrico C. Torre in the lab using KeratoxR


Sarah Greenhalgh, Managing Director of Kerato, commented:
"Kerato's Ocular Toxicity Testing Platform will be transformative, offering a new testing method that can be seamlessly implemented within existing R&D pathways and scaled, helping to meet the growing global demand for alternative and sustainable processes." 

Science


Ocular Toxicity testing is a regulatory requirement for all new-to-market pharmaceutical and consumer goods products to ensure ensure compliance with safety standards. The United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS) classifies chemicals based on their potential to cause adverse effects on human health and the environment.

Current tests are heavily reliant on in-vivo (animal) models.

Building on a strategic relationship with one of the worlds largest consumer goods companies, we are developing an ocular toxicity testing platform that utilises lab-grown corneas as an alternative for evaluating novel chemical formulations.

KeratoxR, will enable companies to test and understand a range of ocular toxicity endpoints through a sustainable and cost-effective method.

The Benefits


High throughput in-vitro test

KeratoxR will provide innovative R&D focused chemical and pharmaceutical companies with an in-house, high-throughput in-vitro test that can be used to evaluate the ocular toxicology of known and novel chemical formulations.

Providing early indications of a formulations’ ocular toxicity profile with reference to UN-GHS, distinguishing between Class I, Class IIa and IIb, and unclassified chemicals.

Reduction in late-stage test fail burden, providing savings to companies

Our product aligns with international policies aimed at reducing the reliance on animal testing and addresses shortfalls in currently available testing solutions


Timeline

2024 - Collaborative Accelerated Knowledge Transfer Project with Newcastle University and 3DBT supported by Innovate UK provided early proof of concept data.

Want to learn more about what we do, and how we could work with your business or research group? Get in touch!
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